interleukin-17 gene expression and serum levels in children with severe asthma
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abstract
background: il-17 is a major cytokine player in t cell mediated leukocyte associated inflammation. il-17 is also recognized to participate in the pathophysiology of asthma. objective: to determine the role of il-17 in predicting severe asthma. methods: we obtained serum samples from asthmatic children under the age of 5-year in three different groups of mild (n=33), moderate (n=28) and severe (n=32) persistent asthma. il-17 serum concentrations and mrna expression were determined by elisa and real time pcr assays, respectively. results: serum il-17 concentrations were significantly higher in patients with severe asthma than the other two groups of children with mild and moderate disease (p=0.00). mean serum il-17 values were 142.04 pg/ml in mild group, 180.4 pg/ml in moderate group and 251.25 pg/ml in severe group. il-17 mrna levels were also significantly elevated in severe asthmatic patients compared to mild and moderate asthmatic children (p=0.00). conclusion: our data reveal an increase in the serum il-17 concentrations and il-17 mrna expressions in children with severe asthma compared to those with mild and moderate forms of the disease.
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Journal title:
iranian journal of immunologyجلد ۱۰، شماره ۳، صفحات ۱۷۷-۱۸۵
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